GPREDICT: Prediction of Glioma Patients' Enrollment In Therapeutic Clinical Trials

GPREDICT allows clinicians and researchers to estimate individual adult glioma patients' probability of enrolling in a therapeutic clinical trial, identify which patient characteristics most influence enrollment probability for a given patient, and generate general and patient-specific recommendations for increasing the probability of accrual.

Demographic Variables
Socioeconomic Variables
Oncologic Variables

* These variables are not incorporated as predictors into the boosted neural network for probability calculations but may help guide recommendations to increase accrual.

Please input the patient's age at diagnosis in the highlighted field to calculate the estimated enrollment probability.

Estimated Enrollment Probability:

General Recommendations for Trial Screening
Screening Discussion Patterns Recommendations
Patient-Specific Characteristics That Most Influence Enrollment Probability
Factors Increasing Enrollment Probability
Factors Decreasing Enrollment Probability
Patient-Specific Recommendations
Patient Characteristics and Context Recommendations
References & Citations
  1. Morshed RA, Reihl SJ, Molinaro AM, Kakaizada S, Young JS, Schulte JD, Butowski N, Taylor J, Bush NA, Aghi MK, Berger MS, Chang S, Clarke J, Hervey-Jumper SL. The influence of race and socioeconomic status on therapeutic clinical trial screening and enrollment. J Neurooncol. 2020 May;148(1):131-139. doi: 10.1007/s11060-020-03503-x. PMID: 32350780.
  2. Oyer RA, Hurley P, Boehmer L, Bruinooge SS, Levit K, Barrett N, Benson A, Bernick LA, Byatt L, Charlot M, Crews J, DeLeon K, Fashoyin-Aje L, Garrett-Mayer E, Gralow JR, Green S, Guerra CE, Hamroun L, Hardy CM, Hempstead B, Jeames S, Mann M, Matin K, McCaskill-Stevens W, Merrill J, Nowakowski GS, Patel MI, Pressman A, Ramirez AG, Segura J, Segarra-Vasquez B, Hanley Williams J, Williams JE Jr, Winkfield KM, Yang ES, Zwicker V, Pierce LJ. Increasing Racial and Ethnic Diversity in Cancer Clinical Trials: An American Society of Clinical Oncology and Association of Community Cancer Centers Joint Research Statement. J Clin Oncol. 2022 Jul 1;40(19):2163-2171. doi: 10.1200/JCO.22.00754. PMID: 35588469.
  3. Unger JM, Hershman DL, Till C, Minasian LM, Osarogiagbon RU, Fleury ME, Vaidya R. "When Offered to Participate": A Systematic Review and Meta-Analysis of Patient Agreement to Participate in Cancer Clinical Trials. J Natl Cancer Inst. 2021 Mar 1;113(3):244-257. doi: 10.1093/jnci/djaa155. PMID: 33022716; PMCID: PMC7936064.
  4. Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA. 2004 Jun 9;291(22):2720-6. doi: 10.1001/jama.291.22.2720. PMID: 15187053.
  5. Reihl SJ, Patil N, Morshed RA, Mehari M, Aabedi A, Chukwueke UN, Porter AB, Fontil V, Cioffi G, Waite K, Kruchko C, Ostrom Q, Barnholtz-Sloan J, Hervey-Jumper SL. A population study of clinical trial accrual for women and minorities in neuro-oncology following the NIH Revitalization Act. Neuro Oncol. 2022 Aug 1;24(8):1341-1349. doi: 10.1093/neuonc/noac011. PMID: 34999844; PMCID: PMC9340618.
  6. Acuña-Villaorduña A, Baranda JC, Boehmer J, Fashoyin-Aje L, Gore SD. Equitable Access to Clinical Trials: How Do We Achieve It? Am Soc Clin Oncol Educ Book. 2023 May;43:e389838. doi: 10.1200/EDBK_389838. PMID: 37146264.
  7. Kim ES, Bruinooge SS, Roberts S, Ison G, Lin NU, Gore L, Uldrick TS, Lichtman SM, Roach N, Beaver JA, Sridhara R, Hesketh PJ, Denicoff AM, Garrett-Mayer E, Rubin E, Multani P, Prowell TM, Schenkel C, Kozak M, Allen J, Sigal E, Schilsky RL. Broadening Eligibility Criteria to Make Clinical Trials More Representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement. J Clin Oncol. 2017 Nov 20;35(33):3737-3744. doi: 10.1200/JCO.2017.73.7916. Epub 2017 Oct 2. PMID: 28968170; PMCID: PMC5692724.
  8. Muthukumar AV, Morrell W, Bierer BE. Evaluating the frequency of English language requirements in clinical trial eligibility criteria: A systematic analysis using ClinicalTrials.gov. PLoS Med. 2021 Sep 14;18(9):e1003758. doi: 10.1371/journal.pmed.1003758. PMID: 34520467; PMCID: PMC8439488.
  9. Medina SP, Zhang S, Nieves E, Dornsife DL, Johnson R, Spicer D, Borno HT. Experiences of a Multiethnic Cohort of Patients Enrolled in a Financial Reimbursement Program for Cancer Clinical Trials. JCO Oncol Pract. 2023 May;19(5):e801-e810. doi: 10.1200/OP.22.00429. Epub 2023 Feb 17. PMID: 36800640.
  10. Borno HT, Zhang L, Siegel A, Chang E, Ryan CJ. At What Cost to Clinical Trial Enrollment? A Retrospective Study of Patient Travel Burden in Cancer Clinical Trials. Oncologist. 2018 Oct;23(10):1242-1249. doi: 10.1634/theoncologist.2017-0628. PMID: 29700209; PMCID: PMC6263122.
  11. Caston NE, Williams CP, Wan C, Ye S, Pywell C, Ingram SA, Azuero A, Sussell J, Patel S, Arend R, Rocque GB. Associations between geography, decision-making style, and interest in cancer clinical trial participation. Cancer. 2022 Nov 15;128(22):3977-3984. doi: 10.1002/cncr.34455. Epub 2022 Sep 16. PMID: 36111955.
  12. Agaronnik ND, Peters MLB, Iezzoni LI. Exclusion of people from oncology clinical trials based on functional status. Clin Trials. 2025 Jan 2:17407745241304114. doi: 10.1177/17407745241304114. Epub ahead of print. PMID: 39744922.
  13. Abi Jaoude J, Kouzy R, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Pasalic D, Verma V, VanderWalde NA, Smith BD, Smith GL, Fuller CD, Das P, Minsky BD, Rödel C, Fokas E, Jagsi R, Thomas CR, Subbiah IM, Taniguchi CM, Ludmir EB. Performance Status Restriction in Phase III Cancer Clinical Trials. J Natl Compr Canc Netw. 2020 Oct 1;18(10):1322-1326. doi: 10.6004/jnccn.2020.7578. PMID: 33022640; PMCID: PMC9671537.
  14. Hutchins LF, Unger JM, Crowley JJ, Coltman CA Jr, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999 Dec 30;341(27):2061-7. doi: 10.1056/NEJM199912303412706. PMID: 10615079.
  15. Hurria A, Dale W, Mooney M, Rowland JH, Ballman KV, Cohen HJ, Muss HB, Schilsky RL, Ferrell B, Extermann M, Schmader KE, Mohile SG; Cancer and Aging Research Group. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J Clin Oncol. 2014 Aug 20;32(24):2587-94. doi: 10.1200/JCO.2013.55.0418. PMID: 25071116; PMCID: PMC4129504.
  16. Scher KS, Hurria A. Under-representation of older adults in cancer registration trials: known problem, little progress. J Clin Oncol. 2012 Jun 10;30(17):2036-8. doi: 10.1200/JCO.2012.41.6727. PMID: 22547597.